Science / R&D
The research intelligence behind Arete — a measurable operating system for performance, recovery and the realisation of potential.
Arete does what no single wearable or app can: it contextualises physiological data within a specific physical environment. WHOOP knows your recovery; Garmin knows your VO₂max. Neither knows what your infrared sauna session did to your HRV overnight. The research question the app must answer: does Arete's sequence of movement → thermal → nourishment → transition produce measurable shifts in DunedinPACE, hsCRP and HRV over a 90-day membership?
DNA-methylation clocks read patterns in your DNA to calculate biological age. Horvath predicts chronological age; PhenoAge tracks disease phenotype; GrimAge is the most mortality-predictive; and DunedinPACE is the speedometer — it measures your rate of aging, not your age. Bryan Johnson's ~0.69 means he ages ~8 months per 12. TruDiagnostic's TruAge runs every clock from one blood draw; SYMPHONYAge breaks the result down per organ system, so we can see which modalities move which organs. The challenge is latency — epigenetic tests run only every 3–6 months, so we build a daily proxy from HRV, resting HR, sleep consistency and VO₂max, calibrated against the quarterly ground truth.
Clocks, DunedinPACE, the 12 hallmarks.
Architecture, circadian rhythm, CAR.
Glucose, insulin, the microbiome.
VO₂max, strength, sarcopenia.
HRV, breathwork, hormesis.
Cognition, BDNF, neuroplasticity.
Testosterone, cortisol, thyroid.
hsCRP, immunity, inflammaging.
The sequence, biomarkers, wearables, plan.
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The full 25-section R&D Intelligence document and live research log sync from Notion. Each subject here is scaffolded with the real research so the shape is right before the connection is wired.